Supplements aren’t magic.
Which might sound a little strange coming from a supplement brand, but it’s true! First, there’s a physical limit to what we can fit into a capsule. Pair that with the lack of meaningful regulations surrounding supplement safety and it’s clear the burden of finding effective options falls on the consumer.
(That’s you!)
In our increasingly complex world it can be near impossible to keep all the information straight — what works, what doesn’t, who you can trust, who you can’t. It’s endless!
But thankfully, you’re not alone in this hunt for high-quality supplements that can help fill nutrient gaps in your diet. We’re here to highlight three supplement brands that are leading the charge for a safer, simpler supplement shopping experience.
Because we’re not just about calling out the skeevy sales tactics we see in the wellness industry. We’re also firm believers in uplifting the small brands who do the difficult work of crafting well-made supplements backed by science.
So read on for an overview of the supplement brands we trust, why we trust them, and what they can do for you and your wellness journey.
In This Article:
- The Simple Answer: 3 Best Supplement Brands of 2025
- What Makes These the Best Supplement Brands of 2025?
- How to Get the Most from the 3 Best Supplement Brands of 2025
The Simple Answer: 3 Best Supplement Brands of 2025
If you’re in a rush, we’ll make this easy for you. The three supplement brands below actually put their money where their mouth is, and that’s why we’re proud to carry them in our shop.
1. Ortho Molecular Products (OMP)
Long-term health heavyweights, OMP has been developing quality supplements for over 35 years. With a myriad of certifications, awards, and accolades to back up their top-tier approach to supplement crafting, OMP has consistently prioritized first-rate raw ingredients in their formulations.
(Wanna know our favorite of their products? It’s SBI Protect — an immunoglobulin supplement designed to bolster gut health.)
2. Nutriplex Formulas
Known and revered for their superior whole-food formulations, Nutriplex supplements are made with only organic and wildcrafted ingredients. Pretty neat, right? For 30 years, Nutriplex Formulas has created supplements with a steadfast commitment to transparency, integrity, and sustainability.
That’s why the Nutriplex Formulas Whole Food Complex is the only thing we recommend besides our own Vital Greens & Reds as far as superfood powders go.
3. Real Mushrooms
Backed by over 40 years of experience, Real Mushrooms was founded to help fight against the lack of scientific evidence to support the efficacy of mushroom supplements. And you can feel good about spending your hard-earned cash on these supplements — Real Mushrooms is one of the only brands around that offers total label transparency.
Our advice? Ditch the fan-favorite fungi companies in favor of Real Mushrooms. Their Lion’s Mane formula is a research-backed option for boosting brain health, cognition, and focus.
Let’s Get Smart: What Makes These the Best Supplement Brands of 2025?
In order for a supplement to make it on our shelves — whether it’s our Woodstock Vitamins brand or not — it has to meet a strict set of criteria.
Dr. Neal dubbed this collection of regulations the Supplement Quality Standard, or SQS for short. While the items on this checklist might seem ridiculously simple… You’d be amazed at how many brands make supplements without considering the science, compliance, virtue, and value of what they provide.
- Science: Our products and the supplement brands we support must be based on real, verifiable scientific evidence. No ifs, ands, or buts.
- Compliance: They must also meet all quality and manufacturing regulations. No corners may be cut around these parts.
- Virtue: The brands we carry have to walk the walk, too. Supplement manufacturers that don’t prioritize the health and longevity of our planet don’t make it in our store.
- Value: Lastly, these products have to be worth the price tag and offer wellness seekers good value per dollar. Price gouging, unnecessary markups, and the like are a quick way to get booted off this list.
It should go without saying, but the three best supplement brands of 2025 — according to our team of supplement strategists lead by Dr. Neal — meet these incredibly exacting requirements. Ortho Molecular Products, Nutriplex Formulas, and Real Mushrooms all provided verified, high-quality supplements but let’s dive into why we love each one in particular.
Ortho Molecular Products
This supplement OG is appreciated by pros for its advanced formulations that target specific health concerns such as immune function, joint health, and digestive support. Plus, their commitment to continuous research is reflected in the way they partner with healthcare professionals to make sure their products align with the latest scientific findings.
The OMP team also emphasizes quality control with their state-of-the-art manufacturing process. (Yes, they’re certified by third-party organizations for Good Manufacturing Practices compliance!) Their continued transparency around sourcing and ingredient quality is another reason they stand out in the crowded supplement market.
Providing science-backed, clinically-tested vitamin and supplement products for over 35 years, Ortho Molecular Products continues to demonstrate their commitment to science, careful ingredient selection and formulation, and strict quality standards with every product.
Learn More: Ortho Molecular Products | Dr. Neal’s Brand Review
Nutriplex Formulas
When it comes to “whole food” products, most manufacturers rely on isolates, or lab made vitamins, minerals, and nutrients. Nutriplex Formulas, on the other hand, uses the whole vegetable, herb, and glandular — and that’s all.
Nutriplex takes the holistic approach to the next level by utilizing organic and wildcrafted ingredients, which preserves the full spectrum of nutrients found naturally in foods. Their products are free from artificial additives, fillers, and preservatives, ensuring a pure, clean supplement.
The brand’s commitment to sustainability is evident in their eco-friendly packaging and responsible sourcing practices, which help reduce their environmental footprint. Nutriplex also prioritizes accessibility to high-quality supplements by offering a wide range of formulas that cater to different health needs, from gut health to energy levels and immune support.
To sum it up: We love Nutriplex Formulas because they focus on whole foods and bioavailable ingredients so that each supplement is as close to nature as possible.
Learn More: Superfood Powders That Stands Up to Scrutiny
Real Mushrooms
You might say: “Real mushrooms? What else would they be?” Well, you’d be surprised. A huge proportion of the ‘mushroom’ products on the market are just mycelium (the mushroom’s root system) grown on a grain substrate. No mushrooms included!
Real Mushrooms, on the other hand, offers 100% real mushroom ingredients, and 100% real results: from cognition and energy to digestion and immunity (and everything in-between), they’ve got an option for you.
That’s how this brand became a trusted name in the industry — because they offer pure mushroom fruiting bodies, the part of the mushroom that contains the highest concentration of bioactive compounds. Plus, they go the extra mile to source their mushrooms from certified organic farms and create products are free from pesticides and heavy metals.
How? By conducting rigorous third-party testing for potency and purity. Hence why we love Real Mushrooms so much — you know exactly what you’re getting in every dose.
Whether you’re looking to boost mental clarity with Lion’s Mane or support immunity with Reishi, Real Mushrooms offers research-backed, high-quality supplements that are well-regarded within the wellness community.
Don’t Forget the Strategy Too: How to Get the Most from the 3 Best Supplement Brands of 2025
The first step in any supplement strategy is starting with top-tier products. While we’re happy to take care of that part for you, we always encourage you to do your own research. We trust these brands, but you don’t have to just take our word for it!
The second step to being strategic about your supplementation is supporting your supplements. We probably sound like a broken record at this point, but say it with us anyway!
You can’t out-supplement a nutritionally bankrupt diet or sedentary, stress-filled lifestyle!
By this we mean that even the best, most effective supplement will only really work if you give it a fighting chance. Start at the bottom of the Wellness Pyramid with lifestyle adjustments in the 5 crucial domains: diet, exercise, sleep, stress management, and environmental changes.

Even a little bit can go a long way. And that leads us perfectly to our last tip for getting the most out of the three best supplement brands of 2025.
Consistency, consistency, consistency.
This applies to both your supplements and your lifestyle adjustments. Consistent is always better than perfect, so aim to incorporate these changes in a sustainable way, even if the steps seem small at first.
Because while all of these supplements have the potential to make a big difference in your well-being, they’re not overnight cures or magic beans. They’re rooted in science, and the science says that most nutritional supplements work in a slow, cumulative manner.
So: Start with brands you trust, support your supplements with lifestyle adjustments, and be consistent. And call us if you need more personalized supplement guidance! Our team of supplement strategists is just a few clicks away.